Although ARC Raiders is currently in a relatively quiet period before its next major update, the development team has made it clear that they don't want player activity to decline. Instead of waiting until October, Embark Studios has continued improving the overall gameplay experience through smaller updates.

Players don't have to wait until October for the next content update. ARC Raiders 1.43.0 update is now live, bringing improved gameplay and anti-cheat enhancements, as well as more personalized outfits, allowing you to showcase your skills in fairer battles.

For a deeper look at ARC Raiders 1.43.0 changes, check related post: ARC Raiders Update 1.43.0: New Set Arrives Alongside Another Account Ban Warning

Season 5 – Week 8 trials and Phantom Targets event  are in full swing, Whether you're working through Weekly Trials, looking for rare blueprints, or for the Phantom Target event, having the right ARC Raiders items can help you spend less time farming and more time focusing on the challenges.

If you don't have enough time to grind materials or repeatedly farm rare blueprint drops, IGGM ARC Raiders Shop offers a wide selection of ARC Raiders itmes, blueprints, materials, weapons and keys that help you complete challenges much faster.

The IGGM ARC Raiders best-selling items list might help you complete the challenges more effectively:

• Assorted Seeds
  
• Familiar Duck
  
• Looting Mk. 3 (Survivor)
  
• Leaper Pulse Unit
  
• Snitch Scanner
  
• [Modded Weapon] Bobcat (Plan C)
  
• [Modded Weapon] Tempest (Plan C)
  
• [Modded Weapon] Renegade (Plan C)
  
• [Modded Weapon] Bobcat (Plan A)
  
• [Modded Weapon] Torrente (Plan C)
  

NBA 2K27 will officially launch its new season on September 4, 2026. Starting August 26th, pre-ordering the NBA 2K27 Deluxe Edition or Ultra Edition will grant you a 9-day early access advantage.

NBA 2K27 MyTEAM mode is expected to be a key element in attracting many players and will feature several community-driven changes, including player experience points, an expanded trading system, a unified auction house, new player card parallel cards, and additional progression features.

For players looking to quickly build a MyTEAM roster, having enough NBA 2K MT makes it easier to utilize these new systems from the start. At the IGGM NBA 2K27 Shop, you can easily buy the number of MT you need, reducing farming time and allowing you to focus more on building the roster you truly want.

In NBA 2K27 MyTEAM, you can redeem almost any player card (including those earned through season rewards) for elite rewards. This gives previously overlooked cards additional value, rather than letting them sit idle in your deck.

With the increasing number of ways to collect, trade, upgrade, and compete, having enough in-game currency is becoming increasingly important for MyTEAM players.

MT is the core currency of MyTEAM mode. Whether you want to strengthen your roster, acquire rare player cards, or take full advantage of the auction house, having enough MT gives you greater flexibility in managing your team.

For more information, you can also view related post: NBA 2K27 Best Meta Point Guard Build Guide: How to Dominate Offense and Defense in MyPLAYER Mode?

Accumulating MT through gameplay is certainly an option, but it can be very time-consuming. NBA 2K27 introduced a brand-new progression system in MyTEAM mode, meaning many players will want to focus their time on actual gameplay and team development, rather than spending all their time farming currency.

Buy NBA 2K27 MT offers a convenient alternative. If you're looking for an easy way to build your MyTEAM roster, the IGGM NBA 2K27 store offers secure and fast NBA 2K MT across all platforms.

Buying NBA 2K27 MT from IGGM lets you skip the tedious grind and instantly acquire the legendary players you want, giving you a competitive edge at the start of each season!

Why choose IGGM to buy NBA 2K27 MT?

Fast Shipping - IGGM is recognized for our 15-minute fast delivery in the entire NBA 2K27 trading market.

Competitive Pricing - IGGM regularly offers discounts and promo codes, allowing players to obtain desired items at prices lower than the average price on other platforms. Prices are transparent, with no hidden fees.

Payment Options - IGGM supports multiple payment methods, including PayPal, Apple Pay, Klarna, Cash App and other secure local payment options. SSL encryption is used to protect user information.

Website Quality - IGGM's clean and intuitive design allows you to quickly find the games and items you need, and browsing and ordering smoothly on both PC and mobile devices.

Trusted Reputation - 4.8/5 Trustpilot rating based on 180K+ verified reviews. 100% APIVoid and 100% ScamAdviser trust score.

100% Safe Trade - No bots, no hacks, no risks of bans.

24/7 Live Support - Always available to help you with your order.

Extra Offers - IGGM Check in, VIP plan, holiday sales, and affiliate available.

Great Returns - IGGM refund policy is clear and transparent, For eligible orders involving non-delivery, incorrect descriptions or faulty products, IGGM provides a transparent refund process. Orders successfully delivered as described or already consumed generally cannot be refunded.

A small tip: Register an IGGM account before purchasing. Registered users can enjoy additional benefits and discounts not available to guest users.

Once registered, you will have VIP 1 status and enjoy a 1% discount. You can also participate in IGGM Check-in (Only for registered users) to earn points. With your spending, you can not only upgrade your VIP level up to five levels and enjoy discounts of up to 5%, but also earn Points Back on Purchases. In the future, you can redeem also specific in-game items with your points. 

How Do I Create An IGGM Account?
Creating an IGGM account is quick and easy. You can register with your email address or use a supported third-party account.

Option 1: Sign Up with Email
- Visit IGGM and click "Sign Up" in the top-right corner.

- Enter your email address and create a password.

- Complete the registration process as prompted.

Option 2: Sign Up with a Third-Party Account
IGGM also supports registration through several third-party platforms. On the sign-up page, you can choose from:

Google · X · Twitch · Steam · Reddit · Discord

Click the platform you prefer and follow the on-screen authorization steps to complete your registration.

How do I earn IGGM points?
- IGGM Check in (Only for registered users)
Check in on the first day to earn 5 points.
Check in on the second day to earn 6 points.
Check in on the third day to earn 8 points.
Check in on the fourth day to earn 10 points.
Starting from the fifth day, earn 10 points for each consecutive day of checking in. If you miss a day of checking in, you need to start over to earn points. After accumulating enough points, you can use points to redeem IGGM Coupon. But each reward is limited to the first 30 users per week on a first-come, first-served basis.

- Points Back on Purchases
Base Ratio: $1 spent = 1 Point.
Rounding Rule: For any order amounts with decimals, points are calculated using the standard rounding principle (rounded to the nearest whole number).
Minimum Threshold: Orders with a Subtotal of less thnerate any points.
Points Distribution: Points are automatically issued once a regular order status is updated to "Completed".
New User 10x Boost: Earn 10x points on your very first order (Min. $1 subtotal). E.g., $1 = 10 Points. Anti-Fraud Mechanism: First order points are not credited immediately. They will be issued to your account balance within 24 hours after successful delivery, provided no refund has occurred.

IGGM Points System & Rules Explained:
Your points can not only be redeemed for coupons but also offset cash; 100 points = 1 USD. But points are valid for 90 days from the date they are earned. A rolling expiration system applies (e.g., points earned on Day 1 will expire on Day 91).



These benefits can make registering worthwhile for players who expect to buy NBA 2K27 MT and mroe others products than once.

How to buy IGGM NBA 2K27 MT?
1. First, go to IGGM NBA 2K27 product page.
2. Select your platform, PS/Xbox/PC/Switch;
3. Select the amount of 2K27 MyTeam Coins to buy, click BUY NOW;
4. Fill in your user and delivery information, and carefully verify the accuracy of all details.
5. Select one payment method and enter the currently available coupon code; Click Pay Now, then wait for us to ship your order.

How to process MT delivery smoothly?
1. Be sure that starting Bid is Randomized and have it close to the actual buyout.
2. Post card's duration for 24 hours is recommended strongly.
3. We Don't cover trade fee.

Note: Do not recommend to list Golden, Green and Blue,Please list Red at buyout price not more than 20K, Amethyst at buyout price not more than 40K. The current bid and the fixed price should not be too far apart. Otherwise, the card cannot be found in AH.

For PC players: There are no specific restrictions on the cards, but need to set the start bid price at 5,150, buy now price at 17,000 max.

Other NBA 2K27 Services from IGGM
Besides MT, IGGM also provides:
VC – Upgrade your MyPLAYER skills and quickly become a superstar.

Players(Upcoming) – Quickly unlock players with super high ratings and build an All-Star roster.

Accounts(Upcoming) – Resource-rich account types that let you skip the beginner stage and jump straight to later content.

Boosting Services – Professional help for leveling and game progression.

All services follow IGGM’s signature fast, secure, and safe delivery system.

Ready to start building your NBA 2K27 MyTEAM roster? Visit IGGM NBA 2K27 MT Store and get your MyTEAM Points ready for the new season.

Madden NFL 27 is now available, bringing a more intense and realistic NFL experience.

If your goal is to quickly build your roster, adjust your team's configuration, or keep up with the constantly changing content in Ultimate Team, strategically managing your Madden 27 Coins is essential.

Why are Madden NFL 27 Coins so important?
In Madden NFL 27 Ultimate Team, players need to continuously acquire new Player Items and adjust their team's roster according to their tactical system. The value of Coins is primarily reflected in the team building process.

For example, when you need to replace a player in a position, add depth to your roster, or find Player Items that better suit your current tactics, MUT 27 Coins can help you make more flexible team adjustments.


While Ultimate Team is heavily focused on collecting Player Items and optimizing your roster, Franchise Mode offers a different approach to team building.

The latest Franchise Mode changes put more emphasis on managing your team over the long term. Contract negotiations, player development, roster decisions, and the overall progression of your franchise can all affect how successful your team becomes.

This makes Franchise Mode particularly interesting for players who enjoy the management side of football rather than simply building the strongest possible roster from available Player Items.

For a deeper look at these changes, check related post: Madden NFL 27 Title Update Guide: Which Bugs Are Fixed on August 26 and Which Problems Are Still Broken?

Although Franchise Mode and Ultimate Team have different progression systems, both modes share one important idea: smart roster management matters. Understanding player value, identifying weaknesses, and making the right roster decisions can have a major impact on your overall Madden NFL 27 experience.

For Ultimate Team players, this makes efficient resource management especially important. The better you manage your Coins, the more flexibility you have when building and rebuilding your team.

How to Get Madden NFL 27 Coins?
Players can earn rewards by completing Challenges, participating in related Events, playing matches, and engaging in various Ultimate Team activities. However, for players with limited daily playtime, relying solely on in-game accumulation can require a significant time investment.

This is why some players seek out methods like Buy Madden NFL 27 Coins, hoping to reduce the time spent repeatedly farming resources and focus more on team composition and the matches themselves.

If you're looking for a reliable website to safely and quickly purchase Madden 27 Coins, IGGM is undoubtedly your best choice for obtaining coins fast and securely. It's best to become an IGGM registered user first. Registered users can enjoy numerous discounts compared to guests.

How Do I Create An IGGM Account?
Creating an IGGM account is quick and easy.

Option 1: Sign Up with Email
- Visit IGGM and click "Sign Up" in the top-right corner.

- Enter your email address and create a password.

- Complete the registration process as prompted.

Option 2: Sign Up with a Third-Party Account
IGGM also supports registration through several third-party platforms. On the sign-up page, you can choose from:

Google · X · Twitch · Steam · Reddit · Discord

Click the platform you prefer and follow the on-screen authorization steps to complete your registration.

Once registered, you will have VIP 1 status and enjoy a 1% discount. You can also participate in IGGM Check-in (Only for registered users) to earn points. With your spending, you can not only upgrade your VIP level up to five levels and enjoy discounts of up to 5%, but also earn Points Back on Purchases.

IGGM Points System & Rules Explained:
NOTE: IGGM Points System only for registered users.
Your points can not only be redeemed for IGGM coupons but also offset cash; 100 points = 1 USD. But points are valid for 90 days from the date they are earned. A rolling expiration system applies (e.g., points earned on Day 1 will expire on Day 91).

How do I earn IGGM points?

- IGGM Check in (Only for registered users)
Check in on the first day to earn 5 points.
Check in on the second day to earn 6 points.
Check in on the third day to earn 8 points.
Check in on the fourth day to earn 10 points.
Starting from the fifth day, earn 10 points for each consecutive day of checking in. If you miss a day of checking in, you need to start over to earn points. After accumulating enough points, you can use points to redeem IGGM Coupon. But each reward is limited to the first 30 users per week on a first-come, first-served basis.

- Points Back on Purchases
Base Ratio: $1 spent = 1 Point.
Rounding Rule: For any order amounts with decimals, points are calculated using the standard rounding principle (rounded to the nearest whole number).
Minimum Threshold: Orders with a Subtotal of less thnerate any points.
Points Distribution: Points are automatically issued once a regular order status is updated to "Completed".
New User 10x Boost: Earn 10x points on your very first order (Min. $1 subtotal). E.g., $1 = 10 Points. Anti-Fraud Mechanism: First order points are not credited immediately. They will be issued to your account balance within 24 hours after successful delivery, provided no refund has occurred.

Why Choose IGGM.com?
Fast Shipping - IGGM is recognized for our 15-minute fast delivery in the entire Madden 27 trading market.

Competitive Pricing - IGGM regularly offers discounts and promo codes, allowing players to obtain desired items at prices lower than the average price on other platforms. Prices are transparent, with no hidden fees.

Payment Options - IGGM supports multiple payment methods, including PayPal, Apple Pay, Klarna, Cash App and other secure local payment options. SSL encryption is used to protect user information.

Website Quality - IGGM's clean and intuitive design allows you to quickly find the games and items you need, and browsing and ordering smoothly on both PC and mobile devices.

Trusted Reputation - 4.8/5 Trustpilot rating based on 180K+ verified reviews. 100% APIVoid and 100% ScamAdviser trust score.

100% Safe Trade - No bots, no hacks, no risks of bans.

24/7 Live Support - Always available to help you with your order.

Extra Offers - VIP plan, holiday sales, and affiliate available.

Great Returns - IGGM refund policy is clear and transparent, protecting user rights and ensuring a safe and reliable trading process.

Note: To request an IGGM refund or return, contact their 24/7 Live Chat with evidence of the issue. It is granted for non-delivery, description discrepancies, or faulty items, while requests made for personal reasons will have a processing fee deducted. Please note that you will not be eligible for an IGGM refund if the order was successfully delivered as described, if incorrect details were provided, or if the items, accounts, or currency have already been used or altered.

How To Buy IGGM Madden 27 Coins?
1. Enter IGGM Madden 27 product page.
2. Choose your platform, PS5/Xbox Series/PC.
3. Determine your server and delivery information: Auction Player.
4. Add the number of coins you need to the shopping cart and click Checkout.
5. Fill in the necessary user and delivery information.
6. Select the appropriate payment method and available coupons and click Pay Now.

Safe Coins Trading Note:
Delivery Method: Player Auction
Regarding this type of delivery, the seller logs into your EA account (Madden 27 Companion account) and hands over the MUT Coins.You don't have to do anything else than wait till the Coins have been transferred. Requirements as below:

1. Must fill out your Madden NFL 27 Companion account access info correctly.
2. NOTE: EA account is your Madden companion account NOT your console account.
3. Please do not log into your account during the service.
4. Make sure your account has at least 3000 coins to start.

Post Player Card (Regular):
1. Due to the price ranges set by EA you may need to list multiple cards to get to your desired amount of coins. How many cards depends on the Max Range for each card.
2. When selecting a card please list it for under the Max Range (about 10%), so that it can easily be found. Ranges change every time a card is sold 10 times
3. Start bid must be high & unique number, post for 24 hours, that can help us find your card easier.
4. IGGM don't bear the 10% trade tax.

Now based on your needs, buy Madden NFL 27 Coins on IGGM to start building your own Madden NFL 27 Ultimate Team.

EA SPORTS FC 27 will be officially released on September 25, 2026. Are you eagerly awaiting the arrival of this highly anticipated game?

In the FC series, player ratings have always been a hot topic of discussion among players, the debate in the community about which superstars are likely to top the list is in full swing.

Following this year's World Cup, player ratings for some football superstars are sure to change. Several players have already emerged as top contenders and are worth watching:

Kylian Mbappé – A perennial contender for the highest rating and one of the most feared attackers in Ultimate Team.

Ousmane Dembélé – His recent performances make him one of the most interesting candidates for a top-tier rating.

Jude Bellingham – A versatile midfielder whose overall usefulness could go beyond his headline rating.

Erling Haaland – A physical and clinical striker who could remain a major early-game target.

Harry Kane – An elite finisher whose shooting could make him extremely valuable.

Lamine Yamal – Perhaps the most promising young player to watch after this year's World Cup.

Rodri – A fascinating candidate for players who value midfield control and defensive strength.

It's worth mentioning that Neymar retired after this year's World Cup. Will EA include Neymar in the FC 27 Hall of Fame or release Neymar icon player cards to attract more players? Let's wait and see.

If a highly sought-after striker or player of your choice becomes available at a price within your budget, having enough coins allows you to easily grab it and build a strong squad instead of waiting for the next opportunity.

Now, IGGM currently offers safe and fast coin sales on PS4/PS5, Xbox One/Series, and PC platforms, allowing players to choose the quantity to purchase based on their squad-building plans. It has decades of experience in in-game currency trading and is familiar with the entire in-game currency trading process, providing the most comprehensive service and the best prices for all players who love online games.

If you become a registered IGGM user, you can immediately enjoy VIP 1 discounts, and up to 5%. And also participate in IGGM Check-in to earn points.

How Do I Create An IGGM Account?
Creating an IGGM account is quick and easy. You can register with your email address or use a supported third-party account.

Option 1: Sign Up with Email
- Visit IGGM and click "Sign Up" in the top-right corner. .

- Enter your email address and create a password.

- Complete the registration process as prompted.

Option 2: Sign Up with a Third-Party Account
IGGM also supports registration through several third-party platforms. On the sign-up page, you can choose from:

Google · X · Twitch · Steam · Reddit · Discord

Click the platform you prefer and follow the on-screen authorization steps to complete your registration.

How to buy IGGM FC 27 Coins?
1. First, go to IGGM FC 27 product page.
2. Select your platform: PS4/PS5, Xbox One/Series or PC.
3. Select the desired coin quantity. Click Buy Now.
4. Please enter your user and delivery information; rest assured that this information is completely secure!
5. Select the appropriate payment method and any available coupons, then click Pay Now.

FC 27 Coins Trading Notes (Must Read Before Placing An Order):
- Delivery Method: Comfort Trade
- Delivery Information: Origin (Web App) Email, Password, and 4 Backup Codes

Please confirm your Email, Password and Backup Codes are correct, or IGGM cannot deliver your coins in timeframe.

• Make sure that your account is available to use transfer market on web app.
  

• Please do not log into the account during the service.
  

• Please make sure your transfer list is empty and have at least 5K on your account.
  

If you purchase in-game currency, items, or services on IGGM.com, you might have noticed their recently overhauled Points & Rewards Ecosystem. At first glance, it looks like a standard loyalty system: earn points on purchases, check in daily, and redeem discounts. However, if you analyze the underlying math, there are strategic ways to squeeze significantly more value out of every dollar spent.

In this guide, we break down the exact mathematical breakeven points between Cash Coupons and Percentage Discount Codes, reveal how VIP Stacking works, and share a step-by-step strategy to maximize your rewards without falling into common traps.

1. The Core Mechanics: How IGGM Points Work
Before diving into the optimization math, here is a quick baseline summary of IGGM's reward system:

• Standard Earning Rate: $1 spent = 1 Point (rounded to nearest whole dollar).
  

• Point Cash Value: 100 Points = $1 (approx. $0.01 per point).
  

• Newcomer Bonus: 10x Points on your first eligible paid order (Order Subtotal Amount ≥$1).
  

• Daily Check-in Streak: Earn 5 points on Day 1, 6 on Day 2, 8 on Day 3, and 10 points/day from Day 4 onwards.
  

• Rolling Expiration: Points expire 90 days from the day they are earned.
  

• $1 Cash Coupon Requirement: Order ≥ $10.
  

• At $10 Order: 3% Off = $0.30 savings vs. $1 Cash Coupon = $1.00 savings. (The $1 Coupon saves 3x more!)
  

• Breakeven Point: $1 / 0.03 = $33.33.
  

• Optimal Strategy: Use the $1 Cash Coupon for orders between $10.00 and $33.33. Switch to the 3% Discount Code for orders over $33.34.
  

• $3 Cash Coupon Requirement: Order ≥ $30.
  

• At $30 Order: 4% Off = $1.20 savings vs. $3 Cash Coupon = $3.00 savings.
  

• Breakeven Point: $3 / 0.04 = $75.00.
  

• Optimal Strategy: Use the $3 Cash Coupon for orders between $30.00 and $75.00. Switch to the 4% Discount Code for orders over $75.01.
  

• $5 Cash Coupon Requirement: Order ≥ $50.
  

• At $50 Order: 5% Off = $2.50 savings vs. $5 Cash Coupon = $5.00 savings.
  

• Breakeven Point: $5 / 0.05 = $100.00.
  

• Optimal Strategy: Use the $5 Cash Coupon for orders between $50.00 and $100.00. Switch to the 5% Discount Code for orders over $100.01.
  

• $8 Cash Coupon Requirement: Order ≥ $80.
  

• At $80 Order: 8% Off = $6.40 savings vs. $8 Cash Coupon = $8.00 savings.
  

• Breakeven Point: $8 / 0.08 = $100.00.
  

• Optimal Strategy: Use the $8 Cash Coupon for orders between $80.00 and $100.00. Switch to the 8% Discount Code for orders over $100.01.
  

• $10 Cash Coupon Requirement: Order ≥ $95.
  

• At $95 Order: 10% Off = $9.50 savings vs. $10 Cash Coupon = $10.00 savings.
  

• Breakeven Point: $10 / 0.10 = $100.00.
  

• Optimal Strategy: Use the $10 Cash Coupon for orders between $95.00 and $99.99. Switch to the 10% Discount Code for orders of $100.00 or more.
  

• Option 1: VIP Discount (1% to 5%) + Direct Point Deduction (up to 10% of order total).
  

• Option 2: Single Coupon Code or Cash Coupon (Standalone only; CANNOT stack with VIP or Direct Points).
  

• Using 10% Coupon (costs 500 points): Total discount = $10.00. Final Price = $90.00 (You have 100 points left).
  

• Using VIP 5 ($5) + 600 Points ($6): Total discount = $11.00. Final Price = $89.00 (Points fully used for max instant savings).
  

President launches TrumpRx.gov website offering Americans discounted prescription drug prices: ‘Historic’
Trump slashes cost of medications through deals with 16 major pharmaceutical companies
By Emma Bussey
Published February 5, 2026 9:42pm EST

President Donald Trump unveiled TrumpRx.gov, a new government-backed website aimed at giving Americans access to discounted prescription drugs.

Speaking at the website launch Thursday evening at the White House, Trump argued that Americans have long paid far more for prescription drugs than consumers in other countries and called the price differences unprecedented.

"Americans have long been paying the highest drug prices anywhere in the world, while other countries often paid pennies on the dollar for the exact same drugs," Trump said. "We were essentially subsidizing the entire world by hundreds of billions of dollars every year."

He added that despite accounting for a small share of the global population, Americans bear a disproportionate share of drug costs.

"The United States is just 4% of the world’s population and consumes only 13% of all prescription drugs," he said before confirming new agreements would change that dynamic.

"Under the agreements my administration has negotiated, the United States will pay the lowest price paid by any other country," he said. "We’re taking the lowest price anywhere in the world. That’s the price you’re going to be paying," Trump added.

"They’re going way down for the United States — by differences of as much as 300, 400, 500, even 600%" Trump said. "In some cases, even more."

Trump announced the website at a White House event alongside Centers for Medicare & Medicaid Services Administrator Dr. Mehmet Oz and National Design Studio Director Joe Gebbia, the Airbnb co-founder advising the administration on digital design and user experience.

The initiative follows agreements between the Trump administration and 16 of the world’s largest pharmaceutical companies under so-called "most-favored-nation" pricing deals.

"All of these discounts and more will be available directly to consumers starting today at TrumpRx.gov," Trump said, adding that 16 of the 17 largest pharmaceutical companies have signed on, with the remaining company expected to join.

In exchange for exemptions from U.S. tariffs, participating drugmakers agreed to lower prices for the federal Medicaid program and extend those reduced prices to cash-paying consumers through TrumpRx.

Among the participating companies are Eli Lilly and Novo Nordisk, which agreed to cut prices on popular GLP-1 weight-loss drugs.

The administration said the agreements are expected to reduce monthly costs for Americans to an average range of $149 to $350.

The administration highlighted price reductions across a range of medications, including inhalers, HIV treatments, diabetes drugs and IVF medications.

Trump cited reductions in weight-loss drugs and inhalers, as well as fertility treatments.

"Novo Nordisk will be slashing the price of Wegovy from more than $1,300 to $199," Trump said. "AstraZeneca is slashing the price of a common inhaler from $458 to $51."

"We’re also delivering historic discounts for couples struggling with infertility," he added, saying manufacturers would dramatically cut the cost of commonly used IVF drugs, including Gonal-F.

The TrumpRx.gov displays discounted prescription drugs, showing users the percentage savings off the original price and generating a coupon for each medication.

Consumers can print the coupon or save it to a mobile wallet and present it at participating pharmacies to receive the discount at checkout. For specialty drugs, the site directs users to mail-order pharmacies that can deliver medications directly to their homes.

According to administration officials, purchases made through the website will generally not count toward insurance deductibles.

https://www.foxbusiness.com/politics/pre...s-historic

• []Nucleocytoplasmic Transport & Shuttling: Vaults are often localized near nuclear pore complexes. They are believed to "shuttle" DNA-damaging chemotherapeutics (e.g., doxorubicin) out of the nucleus and into the cytoplasm, preventing the drugs from reaching their genomic targets [ScienceDirect].[]Drug Sequestration (Cellular "Drug Depots"): Their massive hollow interior (approximately 50,000,000 ų) allows them to sequester toxins. In resistant cancer cells, vault synthesis can increase up to 15-fold, effectively acting as "sponges" that soak up drugs and store them in non-lethal compartments like lysosomes [PubMed].[]Regulatory RNA (svRNAb): Vault RNA can be processed into small RNAs (svRNAs) that function like microRNAs. One specific fragment, svRNAb, has been shown to downregulate CYP3A4, a critical enzyme in drug metabolism, thereby altering how the body processes chemotherapy [PubMed].[]Survival Signaling: The Major Vault Protein (MVP) modulates pro-survival pathways such as PI3K/AKT and MAPK, helping cancer cells evade apoptosis (programmed cell death) even under high chemical stress [MDPI].

• []Hydrophobic drugs (like All-trans Retinoic Acid) that are otherwise difficult to dissolve in the blood [PMC].[]Proteins and enzymes that need protection from degradation by the immune system.

1. []Vault Particles in Cancer Progression & MDR - PMC[]MVP and Apoptosis Resistance - Nature
2. A Novel Nanofrontier in Drug Delivery - Drug Development & Delivery
   

An ECOG-ACRIN imaging study solves a long-standing gap in metastatic breast cancer research and care: accurately measuring treatment response in patients with bone metastases
December 11, 2025


An FDG PET/CT scan uses a radioactive sugar called FDG (fluorodeoxyglucose) to highlight areas of the body with high glucose consumption, such as tumors, which are often highly metabolically active. This helps doctors detect, diagnose, stage, and monitor diseases like cancer.
A major advance in cancer imaging improves treatment decision-making and opens access to clinical trials for patients with metastatic breast cancer that has advanced primarily, or only, to the bones—a historically understudied group.

A prospective, multicenter cancer clinical trial by the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) has validated an improved method for predicting treatment benefits in patients with hormone receptor-positive (HR+) metastatic breast cancer that has spread primarily or exclusively to the bones. These patients make up a large portion of individuals who are living with advanced breast cancer—yet are routinely excluded from clinical trials that rely on standard imaging-based assessments (i.e., RECIST 1.1). The study demonstrated that metabolic change assessed by FDG-PET/CT accurately predicted progression-free survival as early as 12 weeks after treatment initiation.

The study’s lead investigator, Jennifer M. Specht, MD, a medical oncologist at the University of Washington and Fred Hutch Cancer Center, presented the results of the FEATURE trial (EA1183, NCT04316117) at the 2025 San Antonio Breast Cancer Symposium. Heather A. Jacene, MD, a nuclear medicine physician from Brigham and Women’s Hospital and Dana-Farber Cancer Institute, co-led the trial with Dr. Specht.


“Our study provides the first prospective validation of FDG-PET/CT and PERCIST response criteria in patients presenting with bone-only or bone-dominant metastatic breast cancer,” said Dr. Specht (pictured). “This methodology has the potential to inform patients about whether their treatment is working, rather than waiting for late-stage disease progression.”

Bone is the most common site of breast cancer metastases, and patients with this condition often have more indolent disease than those whose cancer has spread to visceral organs, she said.

The FEATURE trial sought to overcome two long-standing limitations in research and care by applying readily available clinical tools.


“Standard imaging methods, such as CT, MRI, and bone scans, can detect metastases but do not accurately assess how well systemic therapies are working," said Dr. Jacene (pictured). "The conventional assessment of treatment response in solid tumors, known as RECIST 1.1, classifies bone metastases as non-measurable and non-targetable.”

FEATURE evaluated FDG-PET/CT, an advanced imaging technique that measures metabolic activity in cancer cells, including bone lesions. The trial utilized the PERCIST criteria to evaluate FDG PET metabolic changes, with a modification to adjust for lower metabolic uptake in bone lesions (mPERCIST). These guidelines are specifically designed for advanced imaging techniques such as PET/CT. Together, these clinical tools have the potential to provide a more sensitive, biologically relevant evaluation of treatment effectiveness.

The FEATURE trial included 138 patients who underwent FDG-PET/CT imaging before starting treatment and again at 12 weeks. Patients were then scanned at regular intervals with standard imaging and followed for clinical outcomes for a minimum of 3 years and a maximum of 5 years.

The trial met its primary objective by demonstrating that test results at 12 weeks after therapy initiation could indicate whether patients would continue to do well without their disease worsening. Patients without progressive metabolic disease (PMD) at 12 weeks after treatment initiation had a median progression-free survival of 1.6 years (19.4 months), compared with a mere 3 months in those with PMD. This finding successfully establishes a correlation between 12-week treatment responses and progression-free survival.

As part of the primary analysis plan, the team evaluated whether FDG-PET/CT modified PERCIST criteria independently predicted PFS. The results indicated that when scans performed at 12 weeks showed no signs of disease progression, the hazard of cancer worsening was approximately 83% lower. This finding is highly statistically significant, underscoring the strong predictive value of early metabolic response.

“The FEATURE trial shows that FDG-PET/CT with mPERCIST is not only feasible, but clinically meaningful for assessing treatment response in this historically understudied group,” said Dr. Specht. “For the first time, we have a clinically accessible strategy to evaluate how well patients with bone-dominant or bone-only metastatic disease are responding to systemic therapy—with accuracy to guide treatment decisions.”

Dr. Jacene added, “We now have the data to support that with FDG-PET/CT, we can measure the ‘unmeasurable’.”

Dr. Specht, Dr. Jacene, and the ECOG-ACRIN research team are calling for continued evaluation of FDG-PET/CT and mPERCIST in clinical trials and for broader integration of metabolic response assessment in patients with bone-only or bone-dominant metastatic breast cancer.

“If we want to improve outcomes, we need to stop treating bone-only or bone-dominant metastatic breast cancer as unmeasurable,” they emphasized. “This study provides a practical solution—one that can help patients receive the right therapy sooner, and that can finally bring this large patient group into the clinical research landscape.”

Results of other secondary objectives will be presented when the data are mature.

This multi-center trial involved investigators and patients at 35 hospitals and cancer centers across the United States and in Ireland. It received support from the National Cancer Institute, one of the US National Institutes of Health, and was accessible through NCI’s National Clinical Trials Network (NCTN) and the NCI Community Oncology Research Program (NCORP).

About ECOG-ACRIN
The ECOG-ACRIN Cancer Research Group is a membership-based scientific organization known for advancing precision medicine and biomarker research through its leadership of major national clinical trials that integrate innovative genomic approaches. Nearly 21,000 member researchers and advocates from about 1,400 academic medical centers and community hospitals collaborate across 40 scientific committees to design studies spanning the cancer care spectrum, from early detection to the management of advanced disease. To learn more, visit www.ecog-acrin.org and follow us on X/Twitter @EAonc, Facebook, LinkedIn, YouTube, and Instagram.

https://ecog-acrin.org/press-release-an-...etastases/

Aligning Development Pathways for Cell-Based Therapies in Small Patient Populations
December 3, 2025

Genetically modified cell-based therapies, such as chimeric antigen receptor T-cell (CAR T) therapies, hold extraordinary promise for patients with rare cancers, but progress can be hampered by regulatory, manufacturing, and financial systems that are not designed to serve very small patient populations. Friends of Cancer Research (Friends) and the Parker Institute for Cancer Immunotherapy (PICI) outlined strategies in a newly published commentary in the Journal for ImmunoTherapy of Cancer (JITC) that address these barriers for therapies under development in small or rare patient populations. 

Access the full commentary here

The commentary, “Enabling Access to Genetically Modified Cell Therapies Through Flexible Approaches to Manufacturing and Cost Recovery,” proposes three key strategies to align regulatory and manufacturing expectations with the operational realities of developing therapies for small populations, enabling timely and sustainable patient access.

Tailored manufacturing and quality measures that maintain rigor while enabling safe and reproducible manufacturing for small populations.
Adaptable regulatory frameworks that support diverse manufacturing models, including centralized, decentralized, and point-of-care approaches.
Sustainable financial mechanisms, such as public-private partnerships or protocols supported by the National Institutes of Health, to sustain development and access, and generate evidence needed for approval. 

“Genetically modified cell therapies are advancing rapidly, but progress will depend on addressing the regulatory, manufacturing, and financial barriers that limit both their development and ability to reach patients.” – John Connolly, Chief Scientific Officer, Parker Institute for Cancer Immunotherapy


“Sustainable development and access to cell therapies, particularly for rare cancers, will require coordinated approaches across sectors. This commentary reflects a shared effort to ensure that innovation in the lab can be readily translated into new treatments.” – Jeff Allen, President & CEO, Friends of Cancer Research


A special thank you to the working group members who contributed to the proposals in this commentary through their participation in planning discussions and review of the accompanying meeting white paper.

For more information on Friends Cell and Gene Therapies project, please visit: https://friendsofcancerresearch.org/cell...therapies/


Authors
Mark D. Stewart,1 Christopher R. Cabanski,2 Jeff D. Allen,1 John E. Connolly,2 Ben M. Beneski,3 Boro Dropulić,4 Steven A. Feldman,5 Lee A. Fleisher,6 Patrick J. Hanley,8 Kristen Hege,9 Natasha Kekre,10 Holly Fernandez Lynch,7 Crystal L. Mackall,5


Affiliations

1.Friends of Cancer Research 2. Parker Institute for Cancer Immunotherapy 3. Allogene Therapeutics 4. Caring Cross 5. Stanford University School of Medicine 6. Rubrum Advising 7. Perelman School of Medicine at the University of Pennsylvania 8. Children’s National Hospital; The George Washington University 9. Independent Advisor 10. University of Ottawa

https://friendsofcancerresearch.org/news...pulations/

Cancer Research Institute Names 26 New Postdoctoral Fellows
December 17, 2025

New York, NY – The Cancer Research Institute (CRI) is pleased to announce the Winter 2025 Class of CRI Irvington and Immuno-Informatics Postdoctoral Fellows, making investments in 26 promising postdoctoral fellowship trainees whose research spans tumor immunology, cancer prevention, data science, and cellular engineering.

This cohort represents a growing need, as fellowship applications dramatically increased this year in the face of funding uncertainty. CRI responded with an ongoing commitment to filling these gaps, funding 50 percent more fellows this year than originally anticipated.

“Postdocs are the invisible engine of biomedical discovery,” said Miriam Merad, MD, PhD, of CRI’s Scientific Advisory Council. “At a time when federal support is faltering, CRI is once again stepping up – just as it did decades ago when cancer immunology had few champions. Supporting these young scientists is not just an act of resilience; it’s a commitment to the future of science and the patients who depend on it.”

Each CRI Fellowship provides $243,000 over three years and supports high-impact research at leading academic institutions.

“A future immune to cancer begins with bold ideas—and the brilliant scientists who pursue them,” said Alicia Zhou, PhD, CEO of CRI. “At CRI, we are proud to support the next generation of leaders in cancer immunotherapy through our steadfast investment in early-career research and training.”

From a single bold idea in 1971 to a global network of more than 1,600 fellows, CRI’s support for early-career scientists has helped turn immunotherapy from a fringe concept into a front-line cancer treatment. Today’s fellows are not just continuing that legacy—they’re redefining what’s possible

https://www.cancerresearch.org/media-roo...-post-docs